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Eli Lily not to launch Cialis in India

May 31, 2007

US drug maker Eli Lily has decided not to launch its blockbuster erectile dysfunction drug Cialis in India. The decision comes after years of litigation with the Indian government on the scope of the new product patent laws.

According to Eli lily India MD, Sandeep Gupta, there were several factors that led to the decision but a few big product launches can be expected.

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“We would be keenly looking new molecules in the area of diabetes, and other therapeutic categories.We will also go through the approval process and at the earliest launch them for the benefit of Indian patients” said Sandeep Gupta, MD, Eli Lilly.

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Hacking sexual pleasure: a hard, slippery problem

May 29, 2007

Everyone wants more pleasure with less effort, so humans have used mechanical augmentation for ages: prehistoric dildos and porn, Kama Sutra treatises, lubes, piercings, and lately vibrators and Viagra. But since sex is really all about electrical nerve impulses, shouldn’t electronics and signal processing be able to enhance pleasure even further? Can’t we geeks contribute technology to our favorite activity?

Unfortunately, technical types often ask “What can we do with our cool tech?”, rather than “How and why does sex feel good?” For example, recent meetings on sex technology (SXSW and Sex Hacks) show a burgeoning interest in hooking up vibrators to iPods, microphones, cellphones, and video games. New inputs, but the same old transducers. So how about starting with the basics of sex instead?
Not-so-basic physiology

Sex is complicated. Desire, engorgement, lubrication. So many sensations: teasing, urgency, incipient climax, contraction, affectionate pair-bonding, sleepiness. And half a dozen hormones or neurotransmitters - testosterone, dopamine, oxytocin, vasopressin, prolactin - both create and respond to sensations and expectations in myriad positive and negative feedback loops. Several different nerve pathways are involved: in the woman, the majority of nerves are in the clitoral head (not the vagina), while the “G-spot” is really the backside of the clitoris. The sciatic nerve is nearby, and an unrelated non-spinal nerve (the vagus) seems involved; at least one woman with a severed spinal cord was still able to orgasm.
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Vascular dynamics and anatomy aside, science hasn’t been much help. Recent MRI images of sex really just show the shape of the interlocking genitals, nothing more. The only way to “measure” sensation is to ask people what it feels like. Even the basics aren’t so basic; in both men and women, orgasmic sensation can sometimes occur without contractions or ejaculation, and vice versa. Such exceptions matter, because “hacking” cares more about how a system can work than how it was designed to work. In this context, having fun and “getting off” aren’t necessarily the same thing.
Why can’t a woman be more like a man?

For most men, it’s enough to have porn, lubrication and a towel; further gadgets are optional. Men comprise most of the hackers and tinkerers, while the sex-toy users are mostly women (at least to judge by the gadgets for sale). But women respond very differently from men.

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Take Viagra, for example. Viagra creates the same engorgement in women as it does in men, but in general women don’t enjoy the sensation; drug-maker Pfizer is reluctantly abandoning its years-long research on “female Viagra” for want of success, despite a huge potential market.

Women’s disconnect between crotch and head can be even greater: recent research shows women can be consciously turned off (”Ick!”) at the very same time they’re physically turned on. Almost no one - let alone geeky tinkerers - really understands how pleasure works, much less how to hack it. Even the basic physical interface from signal to skin hasn’t improved in ages.

How does skin work? Tactile sensations are transmitted by thousands of strain- , pressure- , and vibration-sensitive neurons layered throughout the skin and erogenous tissue: different combinations of neural responses - i.e. different distributions and synchrony of signals - convey sensations of pressure, heat, stroking, slippery, rough, and so on. Only a handful of the “right” neural patterns correspond to real-world stimuli, just like only certain pixel patterns represent real images on a TV.

So even if we could somehow trigger all the neurons individually, it would still be nearly impossible to simulate a realistic physical sensation. Injecting raw electricity through the skin - “electro-stim” - can fire neurons but can’t fool them into creating the right patterns, any more than flashbulbs or white-noise can simulate a TV picture. So raw electricity will always feel, well, electrical. (There is one possible exception: a product, called Slightest Touch, claims to transmit imperceptible levels of electricity through pleasure centers of the pelvis, creating pleasure without any uncomfortable “electrical” buzz. A great idea, if it works).

The necessarily weird feelings of electro-stim are usually used to produce novelty or pain (as a recent demo suggests) rather than pleasure. A much better way to transform electricity into touch is the vibrator, which was invented about a century ago (see the Antique Vibrator Museum), and hasn’t changed too much since: typically, a weighted electric motor spins and shakes, just like in a cellphone. This is a compact and efficient way to convert electricity into motion, but the shaking is still just shaking. At best one can vary the speed of the motor, say by cleverly processing an audio signal to become drive-current

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Vectura’s $1bn talks with big pharma boosted by successful product trial

May 24, 2007

VECTURA, the British biotech firm, is looking to secure more cash from a partnering deal on its premature ejaculation treatment, after better-than-expected phase II results.

The group has been in talks with a variety of big-name pharma companies, understood to include Viagra giant Pfizer and Eli Lilly. But the strong results from the latest trials mean that the Aim-listed company is now seeking better terms from any potential partners.

The treatment is one of two sexual dysfunction products that Vectura is developing, which are expected to have combined sales of up to $1.2bn (£600m, E890m); the other is for erectile dysfunction. It is thought that current partnering talks are focused on finding a larger company who will help fund end-stage tests for both treatments.

The sexual dysfunction market has huge potential; annual sales are currently around $3bn. The market is dominated by erectile dysfunction treatments, but annual sales are set to hit $7bn by 2012 as products for other conditions successfully come to market.

Vectura is unlikely to finalise a partnership agreement for several months. But the City is optimistic that the firm will secure a strong deal. Said one analyst: “Vectura are one of the best companies in the UK at doing deals. Whatever deal they do will probably be the best they could hope to get.”

The premature ejaculation inhaler showed positive results within 15 minutes of most patients taking it. There is currently no medical treatment available for the condition.

Its erectile dysfunction product, which is also inhaler-based, works in a different way to Viagra, which currently dominates the market, and Lilly’s Cialis. That means it could target the 30% of sufferers who don’t respond to existing drugs. In trials, it worked within five to 10 minutes compared to an hour for Viagra for 85% of patients.

Vectura also specialises in inhaled products for lung diseases, and is rumoured to be working on a generic version of GlaxoSmithKline’s asthma inhaler Advair, due to come off patent between 2010-12.

The company has a market cap of £275m and plans to apply to move to the main market in July.

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Thanks Henrik. Now Do One

May 21, 2007

It`s been a mixed couple of weeks for the Whites. Big Sam`s gone and been replaced by Chucky, the evil ventriloquist`s dummy. Bolton have qualified for Europe, but the rumours surrounding the Reebok are multiplying quicker than a Blackburn family who`ve discovered viagra.

Four players were released last week, Henrik Pedersen amongst them. The less than great Dane, played at both centre-forward and full back and was equally bad at both. His level of effort and commitment was appreciated though, and he`ll be missed, especially by pub landlords in Atherton.

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Also given the boot were mini-thug and arch balloon popper David Thompson, club cripple, Quinton Fortune and Spanish defender, Cesar Martin, who was pursued by Sam Allardyce for two years, for reasons known only to him.

The latest brain dead rumour links goalkeeper Jussi Jaaskelainen with Sunderland. C`mon lads. I know you`ve got pages to fill, but surely you can come up with something more plausible than that.

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Anti-addiction Therapies, 2006-2011- The Pharmaceutical Industrys Next Viagra?

May 21, 2007

More money is spent advertising alcohol than any other product. For some, it like gambling and cigarettes are pleasant distractions, yet for others they are the generators of unbearable cravings and the cause of considerable distress. For them their addition is a disease. According to a new report - Anti-addiction Therapies, 2006-2011 - society is crying out for solutions. Which pharmaceutical companies are now aiming to be that cure? This report will tell you.

Doctors and concerned specialists have long maintained a behavioural-based approach to treating addiction is the most effective treatment programme. Suggested pharmaceutical solutions simply did not work. That is it seems…until now. Two leading pharmaceutical companies have developed novel drugs that could revolutionise the treatment of obesity and nicotine addiction. And what is more, those drugs could save health authorities millions of dollars. With the pharmaceutical industry anxiously seeking the next blockbuster product, it is hardly surprising that Chantix and Acomplia are generating so much interest. Are these drugs set to shift the focus of the pharmaceutical industry? Find out today.

Will these drugs really make much of a difference for such complex disorders? Is this not just the industry wary of decline seizing an opportunity to make money? Anti-addiction Therapies, 2006-2011 - assesses the currently available drugs, analysing which pipeline drugs appear to fit unmet needs best. This report also examines which pharmaceutical companies are likely to be market leaders by 2011.

Pfizer’s Chantix, for the treatment of nicotine addiction, and Sanofi-Aventis’ Acomplia might provide not only much needed effective relief to thousands of addicts, but could also help develop and drive a market as Viagra did for erectile dysfunction. Markets that are currently worth $1 billion could multiply several-fold within the foreseeable future.

“If Chantix and Acomplia prove to be as effective, but with the minimal side effect profiles that Pfizer and Sanofi-Aventis claim, then we could see significant development in these treatment markets,” commented visiongain market analyst and author of this latest report, Tristan Heath. This optimism is based upon the increasing incidence of obesity throughout the developed world and the stated wish of 70% of smokers to quit tobacco. Health authorities throughout the developed world have placed these health issues as top priorities. This is a potential market you cannot afford to ignore. Imagine the potential success your company could aachieve through being informed of this market now.

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Treatment can be tailored to the individual and typically involve a combination of drug and behavioural therapy. Treatment of drug addiction is usually a long, multi-stage process. Encouragingly, modern drug-dependency treatment regimes are generally believed to be effective, with 40-70% of patients successfully recovering from their addiction. Can that same success be repeated in other addictions. Find out now by simply placing your order for this business critical report.

What is in the report?

- Statistics of addiction, including potential patient populations and the economic burden of addiction.
- Drug addiction - Heroin and cocaine addiction treatments, including the development of vaccinations for cocaine addiction.
- Alcohol addiction - A review of the new products for the treatment of alcohol addiction, largely those that have been indicated for the treatment of depression or opioid addiction.
- Smoking addiction - Potentially a huge market. Many health authorities have placed smoking as a priority. Pfizer have recently launched Chantix, which is likely to be the first specific treatment for smoking that is an alternative to the nicotine replacement.
- Gambling addiction - A market that is more potential than current reality. It faces difficulties in both developing effective treatments and overcoming cultural perception that gambling is not something that should necessarily be treated by a pharmaceutical.
- Obesity treatment - Potentially the largest market. The prevalence of obesity is increasing, with Sanofi-Aventis having recently launched Acomplia.
- Pipeline products - The interest in the addiction markets stems from the potentially large patient populations and also the large number of products in the pipeline.
- World market by country region for the specific treatment markets. Specific drivers and restraints for the addiction treatment markets are considered.
- Unique research and primary information unavailable elsewhere

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Viagra ad blitz left women out of the equation

May 16, 2007

WASHINGTON — When Pfizer’s market strategists were shaping attitudes toward Viagra in the late ’90s, they had little to say to women. That seems to have been a mistake, and a factor in unimpressive sales in recent years.

The campaign had just one goal: to destigmatize impotence in men so they’d talk to their doctors about the problem and ask for Viagra. The effort succeeded. Viagra’s 1998 launch was the most successful drug introduction ever.

But aside from telling women that a drug to fix erectile dysfunction existed, which many found to be great news, the campaign gave no role or voice to the partner who sex therapists say usually controls intimacy.

At the same time, Viagra required women to buy into a strict new lovemaking time regimen: roughly an hour’s wait before the drug took effect and then sex before it wore off in four to six hours.

In theory, prescribing doctors would counsel couples, bringing women into the picture. In practice, time-strapped internists and general practitioners often see only the men.

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Dr. Abraham Morgentaler, the author of the book “The Viagra Myth: The Surprising Impact on Love and Relationships,” thinks that many women never fully endorsed the drug for use in their love lives.

“Often, it doesn’t fit their idea of what sex should be,” he said. “It’s not spontaneous; it’s not romantic; there’s planning involved. Or the woman wonders, ‘Why does my husband need a pill to have sex with me? Why am I not enough?’ ”

(Not surprisingly, Viagra’s most successful competitor is Lilly ICOS’s Cialis, whose ads show blissed-out couples and tout the drug’s 36-hour window for sex.)

Feminists raise more basic objections to the drugs. Dr. Leonore Tiefer, an associate professor of psychiatry at the New York University School of Medicine, argues that the drugs promote intercourse-focused sex at the expense of other forms of lovemaking that women often find more gratifying.

She and many other clinicians say the drugs’ makers reduce the rich complexity of sex by defining it as a strictly physical event in order to sell a pharmaceutical solution when it fails. Their term for what the industry is marketing is “medicalized” sex

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DID LITTLE BLUE PILL REALLY CHANGE WORLD?

May 15, 2007

WASHINGTON — When Viagra came on the market nine years ago, Time worried that it signaled “the end of sex as we know it.” Playboy predicted a sexual revolution “as monumental as the birth control pill.” Adweek forecast demand for Viagra so massive that “not one dollar need ever be spent advertising it.”

It certainly hasn’t worked out that way.

Prescriptions for erectile-dysfunction drugs, which sparked a veritable gold rush to doctors’ offices initially, have been steady worldwide for three years despite massive promotional campaigns.

So the first finding about how erectile-dysfunction drugs changed American life is: less than expected.

The drugs made erection problems widely discussable for the first time. They made chemically assisted sex acceptable among law-abiding people. They enhanced the potential for sex among older Americans. For younger ones, the drugs reportedly made dating life more ardent, stressful and sex-centered.

The drugs indisputably helped millions of men by making their erection problems mentionable.

“That was a very big deal,” said Dr. Judy Kuriansky, a longtime sex counselor on radio, based in New York. “Before Viagra, a lot of men with erection problems were angry and withdrawn in their relationships. They didn’t want sex; their partners didn’t know what was going on; the women blamed themselves, and it was a mess.”

Today, “talking about erection problems is no more stigmatized than talking about feeling depressed,” according to Kuriansky. Yet for every man who has sought treatment, several more never have, surveys determined, and that more than anything suppressed the market for the drugs and the ballyhooed revolution.

And those who did try the drugs had mixed results.

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First, consider men with erection problems. An AARP sexuality survey of men and women 45 and older shows that men treated for erectile dysfunction reported more and better sex. In addition, 56 percent of the men said it improved their relationships. Virtually all the rest said treatment — mostly but not always with drugs — neither helped nor hurt their relationships.

The increased satisfaction extends to their partners, according to a recent study sponsored by Viagra’s maker, Pfizer.

For a second group — younger men who take the drug simply to enhance performance — results are more mixed.

Dr. Abraham Morgentaler, a Boston urologist who teaches Harvard Medical School students, thinks many are responding to pressure from sexually ardent women. Such women have become more numerous and aggressive in recent years, especially in urban areas, said Morgentaler, the author of The Viagra Myth: The Surprising Impact on Love and Relationships.

A third very large group consists of men who tried the drugs but only briefly.

About half of men for whom erectile-dysfunction drugs are prescribed don’t renew prescriptions, surveys indicate, and one popular explanation is the dumb-lovers theory. By that scenario, the husband takes his Viagra, sits down to watch TV and his wife tells him to come upstairs when he’s aroused.

That won’t happen without foreplay or fantasizing, experts know, because the drugs aren’t aphrodisiacs.

Erectile dysfunction isn’t the whole issue in intimacy problems. It’s simply the piece that medicine has learned to fix.

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Protect yourselves, single seniors

May 10, 2007

Many people older than 50 who become single are a bit naive and gullible. That is understandable — some haven’t had a date with anyone other than their spouse in 30 or 40 years.

Sadly, some fall into unfortunate situations that had they known about beforehand, could have been avoided. As an older single, you need to protect four things when dating again.

Protect your heart

Perhaps you are lonely and desperately want companionship. You miss sharing and feel empty. You’re vulnerable and can easily let your guard down.

One widow who considers herself to be intelligent, street-smart, well-educated and grounded became involved with a “wonderful” man. He filled the big, empty space in her life. But a telephone call from the man’s aunt revealed a dark side. He was a liar and a con artist. She found out before major damage was done, but her heart was bruised.

While loneliness is difficult, having one’s heart broken is worse. Be careful where you allow your heart to lead you. Trust your instincts. If something or someone is too good to be true — well, you know the rest of that sentence.

And for sure, if you meet someone you really like, don’t smother him (or her). That’s the quickest way to blow a relationship.

Protect your health

With the proliferation of male enhancement drugs such as Viagra, Levitra and Cialis, some older men think they’re the king stud and expect sex like dessert after dinner. The danger of getting a STD exists among the older set. And it’s not just men who transmit STDs. Women can also be carriers. Both sexes need to be cautious.

Judy Fink, of the AARP in Washington, D.C., says reckless sex at any age can be dangerous.

There are “serious health risks from unprotected sex,” she says. “HIV and AIDS are increasing in people over 50 — heterosexual folks — deciding to become sexually active without testing themselves and their potential partners.”

Walk away from sex if you’re being rushed. Don’t become a statistic. For safe sex guidelines and HIV risk factors, go to the Centers for Disease Control Web site at www.cdc.gov.

Protect your drink glass

“What?” you ask.

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One woman had a couple of dates with a perfect gentleman. Then, he invited her to his house for dinner. After dining and nice conversation, she woke up nude at three in the morning in his bed. He had placed a date-rape drug in her wine glass. Not in a bar, not by a stranger, but by a man she trusted and enjoyed.

When you’re among strangers having a drink — wine, soda, coffee, fruit juice — don’t let your glass or cup out of your sight from the moment the bartender pours it. This is a sad state of affairs, but be aware of the possibility of your drink being spiked.

Protect your assets

It’s sad when you read in the paper about older people being scammed.

In 1999, a 61-year-old man was sent to prison for the third time for defrauding women. He’d been married 11 times and had masqueraded as a fireman, racecar driver, contractor and pilot.

Widows are particularly vulnerable. Many are lonely and their husbands may have made the financial decisions. Mr. Right comes along, gains a widow’s love and trust, and offers to help with finances. If that sounds familiar, have your new beau checked out by a private investigator.

Singles using the Internet to meet mates need to be aware of the “sweetheart scams” now abounding, primarily out of Nigeria. These scammers take advantage of singles’ loneliness and slowly draw them into their web. More than 2,000 people who have been scammed for over $2 million have banded together on Yahoo! groups to fight romance scammers.

Singles need to be in control of their money. One woman co-mingled her funds with her new husband “to prove her love for him.” He kept his assets separate. In the divorce, he got half of her assets and kept all of his. She’ll have to struggle the rest of her life.

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The You Decade is in full swing

May 8, 2007

I suppose I started to notice it about two or three years ago, when the salespeople at Rite-Aid began wearing dish-sized lapel buttons stating that “YOU are the most important customer I will serve today.” It was all wrong, in the same way that a sign hung on a door saying “Back in five minutes” is out of time as soon as it is put in place.

It was wrong in other ways, too, since it could be read from some distance (say, from 10 spaces back in a slow-moving line) and thus became an irritant to anyone who could grasp that “they” – or the “we” of this putative “you” – were not really important at all. As in “your call is important to us” – but not important enough for us to supply enough operators to get you out of the holding pattern and the elevator or fasten-your-seat-belt music that comes with it.

The annoying lapel button was soon discontinued, and the bright consultant who came up with it was no doubt promoted to higher things, but “You” retained its centrality. A room-service menu, for example, now almost always offers “your choice” of oatmeal vs. cornflakes or fruit juice as opposed to vegetable juice. Well, who else’s choice could it be? Except perhaps that of the people who decide that this is the range of what the menu will feature.

Fox News famously and fatuously claims: “We report. You decide.” Decide on what? On what Fox reports? Online polls promise to register what “you” think about the pressing issues of the moment, whereas what’s being presented is an operation whereby someone says, “Let’s give them the idea that they are a part of the decision-making process.”

The next time you see an ad, the odds are increasingly high that it will put “you” in the driver’s seat. “Ask your doctor if Prozac/Lipitor/Cialis is right for you” – almost as if these medications could be custom made for each individual consumer.

Probably the most famous propaganda effort of the 20th century, a recruiting poster with Lord Kitchener pointing directly outward and stating, “Your Country Needs YOU,” was only rushed onto the billboards when it suddenly became plain that the country concerned needed several hundred thousand recruits in a big hurry and couldn’t afford to be too choosy about who it was signing up.

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Tourist posters are even more absurd. I saw one once for Cyprus, showing an empty beach with the slogan, “Keep It to Yourself.” Probably at least a million of these were printed and distributed, with the result that the hotels on the island blocked out the sun on those unspoiled beaches. (Have you ever seen an inducement for a holiday that showed more than two people on the beach? Jamaica welcomes you – but isn’t dumb enough to show you alone on the sand without a girlfriend/boyfriend. It just omits all the other “you” – targets who would otherwise mutate rather swiftly and disconcertingly into “them.”)

I have just been sent a link to an Internet site that shows me delivering a speech some years ago. This is my quite unsolicited introduction to the now-inescapable phenomenon of YouTube. It comes with another link, enabling me to see other movies of myself all over the place. What’s “You” about this? It’s a MeTube, for me.

Perhaps global-scale problems and mass-society populism somehow necessitate this unctuous appeal to the utter specialness of the supposed individual. What you can do to stop planetary warming. How the maximum leader is on your side. The ways in which the corporation has your needs in mind as it makes its dispositions. The candidate who wants to hear your views.

Or, a little farther down the scale of flattery and hucksterism, come to our completely uniform and standardized food outlet and create your own salad and dessert, from our own pre-selected range of freshly prepared and tasteless ingredients!

So, whatever happened to the Me Decade? The answer is that nothing happened to it. It mutated quite easily and smoothly into a decade centered on another narcissistic pronoun. Which pronoun is that? You be the judge.

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